Pathogen-inducible OsMPKK10.2-OsMPK6 cascade phosphorylates the Raf-like kinase OsEDR1 and inhibits its scaffold function to promote rice disease resistance

Mitogen-activated protein kinase (MAPK) cascades regulate a myriad of plant biological processes, including disease resistance. Plant genomes encode large number MAPK kinases (MAPKKKs) that can be divided into two subfamilies, namely MEKK-like and Raf-like kinases. Thus far, the functions MAPKKKs have been relatively well characterized, but roles in remain less understood. Here, we report role OsEDR1, MAPKKK, regulation cascade rice response to bacterial pathogen Xanthomonas oryzae pv. oryzicola (Xoc). We found OsEDR1 inhibits OsMPKK10.2 (a kinase) activity through physical interaction. Upon Xoc infection, is phosphorylated at S304 activate OsMPK6 MAPK). Interestingly, activated phosphorylates S861, which destabilizes thus releases inhibition OsMPKK10.2, leading increased enhanced resistance plants Xoc. Taken together, these results provide new insights immunity.